Total-Body Reset: Powered by 15 Senolytic Compounds*

Helps eliminate “zombie” senescent cells*^1-9
Promotes youthful, high-functioning cells*^1-8,10
Helps maintain a healthy inflammatory response*^7,8,11-16
Supports total-body tissue rejuvenation*^7,12,17,18
Strategic 3-day protocol—modeled after leading senolytic research*^1,5,14,19

A Broader, Deeper Cellular Cleanse*

As we age, “zombie” senescent cells accumulate throughout the body—releasing pro-inflammatory signals that impair cellular function, accelerate aging, and compromise tissue health. While individual compounds like quercetin and fisetin show individual promise, emerging research suggests that multi-senolytic strategies—combining multiple ingredients that act through complementary pathways—may offer a broader and more effective approach to clearing senescent cells across multiple tissues.*^1-9

Rapid Reset Multi Senolytic delivers a powerful combination of 15 senolytic ingredients in a doctor-formulated 3-day protocol. Designed to activate the body’s natural clearance and renewal mechanisms, this high-intensity, low-frequency regimen is designed to spark the body’s natural senolytic mechanisms—promoting head-to-toe rejuvenation. Whether you're new to senolytics or upgrading your monthly longevity routine, this is ProHealth’s most comprehensive cellular reset yet.*^{1-10,12,14-19}

What Makes Ours Better?

Multi-Ingredient Strategy: Combines 15 carefully selected ingredients—each chosen for its unique senolytic potential—to target aging cells through complementary mechanisms.*^1-9,12,15-18
Ultra-Pure Sourcing: Uses high-quality, research-backed ingredients for purity, consistency, and results you can trust.*
Advanced Absorption Technology: Features next-gen delivery systems like FenuMat® quercetin, liposomal resveratrol, and turmeric phytosome for enhanced bioavailability where it counts.*²⁰
Clinically Researched Compounds: Includes well-studied senolytics like fisetin and quercetin, plus Senactiv®—a patented ingredient shown in human studies to reduce senescent cells in exercising skeletal muscle.*^1-9,12,15-18
3-Day Protocol: Built on the “hit-and-run” senolytic model, this short-duration strategy is designed to selectively clear senescent cells while minimizing effects on healthy tissue.*^1,5,14,19

The ProHealth Difference

Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
Triple Lab Tested: Rigorously tested three times by independent third-party labs to guarantee unmatched potency and purity.
 Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle. 
Manufactured in the USA: Since 1988, we’ve proudly produced our supplements in FDA-regulated, GMP-certified facilities, ensuring the highest quality and safety standards.
100-Day Risk-Free Guarantee: We stand behind our products. If you’re not completely satisfied, contact our Santa Barbara, CA office for a full refund—no hassle, no questions asked.

The Ultimate Weapon Against Zombie Cells*

As cells age or become damaged, they can enter a state called senescence—where they stop dividing but don’t die. Instead, they linger in the body as so-called “zombie cells,” releasing a mix of compounds known as SASP (Senescence-Associated Secretory Phenotype), which can influence surrounding cells and affect normal tissue function. Over time, senescent cells tend to build up in areas like the joints, skin, lungs, blood vessels, and fat tissue—contributing to many of the visible and invisible effects of aging.

Why Senolytics Matter

Senolytics are a class of compounds that support the body’s ability to target and clear dysfunctional cells, promoting cellular balance and healthy tissue renewal.*^1-10 However, there’s a challenge: not all senescent cells are the same. These cells can vary in several ways:

Resistance to clearance
Location of accumulation in the body
Signaling molecules they release

Due to this variability, while single-ingredient senolytics can offer targeted support, a multi-senolytic strategy is more effective. It casts a broader net, helping to address diverse senescent cell populations across multiple tissues and cell types.*^1-3,5-8,10

Introducing: The 3-Day Rapid Reset Protocol

This science-backed protocol uses short bursts of high-intensity senolytic activity—also known as a “hit-and-run” strategy—to help clear lingering senescent cells and support full-body cellular renewal.*^{1-9,12,14,17,19,28}

How to Use:

Take ten (10) capsules daily for 3 consecutive days
Discontinue use on day 4
Wait 4–6 weeks before repeating the cycle

This intermittent approach is designed to deliver meaningful results in a compact timeframe—without the need for continuous supplementation.*^1,5,14,19

For ongoing cellular support between senolytic cycles, daily antioxidant compounds like Quercetin or Fisetin can help maintain a healthy internal environment.*^1-7

A Word from our Chief Science Officer

“Clearing senescent cells is one of the most promising frontiers in longevity science. While single-agent protocols are a good starting point, aging is complex, and senescent cells behave differently depending on the tissue and the signals involved. That’s why our Rapid Reset Multi Senolytic takes a broader, more comprehensive approach, combining 15 potent compounds into an easy-to-follow 3-day protocol. This is a new benchmark in senolytic support.”

Ingredient Highlights

Senactiv®: A proprietary blend of extracts from Panax notoginseng and Rosa roxburghii, clinically shown to help reduce senescent cells in muscle.*
Fisetin: A polyphenol found in fruits like strawberries and apples, shown in studies to be one of the most potent senolytic agents available today.*
Quercetin: Often combined with other compounds, this flavonoid has been studied for its role in promoting the removal of senescent cells and improving age-related conditions.*
Trans-Resveratrol: A polyphenol commonly found in red grapes, known for activating longevity-associated sirtuins and supporting heart and brain health.*
Curcuminoids: A group of yellow pigments extracted from turmeric root, commonly used to support a healthy inflammatory response.*
Citrus Peel Blend: Powerful polyphenols derived from citrus fruits, recognized for supporting healthy blood vessels and combating free radicals.*
Phycocyanin: A blue pigment derived from blue-green algae, valued for its antioxidant properties and ability to support cellular health.*
Theaflavins: Unique polyphenols formed during the fermentation process of black tea, when catechins (the primary antioxidants in green tea) are converted into theaflavins.
EGCG: One of the most active and studied types of catechins in green tea, known for boosting metabolism and protecting cells from oxidative stress.*
Apigenin: A flavonoid commonly found in parsley, chamomile, and celery, shown to target the CD38 enzyme and support healthy NAD+ levels.*
Rutin: A bioflavonoid related to quercetin, known for its strong antioxidant properties and its key role in supporting vascular health.*

Pioneering Health and Wellness Products Since 1988

For nearly four decades, ProHealth has been dedicated to crafting the world's highest-quality supplements—rooted in innovation, integrity, and a passion for healthy aging. With a long-standing A+ rating from the Better Business Bureau, our reputation for purity and potency has made us one of the most trusted names in the industry. Our commitment to scientific rigor, premium sourcing, and results you can feel continues to drive everything we do.

References:

Mahoney SA et al. Aging Cell. 2024;23(3):e14060.
Yousefzadeh MJ et al. 2018;36:18-28.
Zhao R et al. PeerJ. 2023;11:e16463.
De Sousa Lages A et al. Int J Mol Sci. 2022;23(17):9957.
Lorenzo EC et al. Front Aging. 2023;4:1161799.
Tavenier J et al. Mech Ageing Dev. 2024;222:111995.
Deledda A et al. Int J Mol Sci. 2022;23(24):16219.
Wiciński M et al. Nutrients. 2023;15(16):3578.
Zhu Y et al. Aging Cell. 2015;14(4):644-658.
Zheng LT et al. Int Immunopharmacol. 2008;8(3):484-494.
Dias E, Poojary DD. 2024;6(3).
Mbara KC et al. Pharm Med. 2022;36(6):331-352.
Khan N et al. Antioxid Redox Signal. 2013;19(2):151-162.
Sun Y et al. Life Med. 2022;1(2):103-119.
Della Vedova L et al. Pharmaceuticals. 2025;18(2):138
Pirmoradi S et al. Drug Res. 2018;68(04):213-221.
Wu J et al. J Ginseng Res. 2019;43(4):580-588.
Sohn EJ et al. Am J Chin Med. 2018;46(04):853-873.
Hickson LJ et al. EBioMedicine. 2019;47:446-456.
Joseph A et al. ACS Omega. 2022;7(50):46825-46832.

Supplement Facts
Serving Size: 10 Capsules
Servings Per Container: 3
Amount Per Serving		%DV
Fisetin (from Rhus succedanea Stem Extract)	1,500 mg	†
Fenumat® Quercetin Complex (from Sophora japonica Flower Buds, Fenugreek Seeds, Sunflower Lecithin)	1,000 mg	†
Veri-te® Trans-Resveratrol	500 mg	†
Meriva® Turmeric Phytosome™ (Curcuma longa Root Extract/Phospholipid Complex from Sunflower)	500 mg	†
Citrus Peel Blend Hesperidin, Naringin, Tangeretin, Nobiletin	400 mg	†
Phycocyanin (from Blue Spirulina (Arthrospira platensis) Whole Algae Extract)	300 mg	†
Theaflavins (from Black Tea Leaf Extract)	275 mg	†
EGCG (from Green Tea Leaf Extract)	200 mg	†
Apigenin (from Apium graveolens Seed Extract)	150 mg	†
Rutin (from Sophora japonica Flower Buds)	100 mg	†
Senactiv® (Panax notoginseng Root Extract, Rosa roxburghii Fruit Extract)	50 mg	†
† Daily Value (DV) not established.

FenuMat® is a registered trademark of Akay USA, LLC, an Oterra company. Veri-te® is a registered trademark of the Lallemand group. Meriva® and Phytosome™ are trademarks owned by Indena S.p.A., Italy. Senactiv® is a registered trademark of NuLiv Science USA Inc.

REV.05.25

OTHER INGREDIENTS: Cellulose (capsule), rice flour.
SUGGESTED DAILY USE: Take ten (10) capsules per day on 3 consecutive days. Wait 4 weeks before repeating. Use monthly for best results.
CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.

Senescence / Autophagy

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Rapid Reset Multi-Senolytic - 30 capsules